Oxyalkylene phosphate compounds and uses thereof

A compound represented by the formula:

• ##STR13## wherein A is ##STR14## and wherein R is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl or C.sub.2 -C.sub.10 alkynyl, each optionally substituted with at least one amino, acylamino, halo, trifluoromethyl, hydroxy, alkoxy, alkyl, acyl, aryl, heteroaryl, substituted heteroaryl group or combination thereof;
• R.sup.1 and R.sup.2 are each independently H or C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl wherein the alkyl, alkenyl or alkynyl group or combination thereof is optionally substituted with halo or alkoxy;
• X is A, R.sup.4 or OR.sup.5, wherein
• R.sup.3 and R.sup.5 are both H or each is independently C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl, aralkyl, aryl, heteroaryl or heteroaralkyl;
• and
• R.sup.4 is C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl, aralkyl, aryl, heteroaryl or heteroaralkyl;
• or both X and OR.sup.3 are A.

A pharmaceutical composition comprising a therapeutically-effective amount of a compound represented by the formula:

• ##STR15## wherein A is ##STR16## and wherein R is C.sub.3 -C.sub.10 straight chain alkyl, C.sub.2 -C.sub.10 alkenyl or C.sub.2 -C.sub.10 alkynyl, each optionally substituted with at least one amino, acylamino, halo, trifluoromethyl, hydroxy, alkoxy, alkyl, acyl, aryl, heteroaryl, substituted heteroaryl group or combination thereof;
• R.sup.1 and R.sup.2 are each independently H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl, wherein the alkyl, alkenyl or alkynyl group or combination thereof is optionally substituted with halo or alkoxy;
• X is R.sup.4 or OR.sup.5, and
• R.sup.3 and R.sup.5 are both H or each is independently C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl, aralkyl, aryl, heteroaryl or heteroaralkyl;
• R.sup.4 is C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl, aralkyl, aryl, heteroaryl or heteroaralkyl;
• with the proviso that when R is n-propyl and R.sup.1 or R.sup.2 is H and the other is trichloromethyl, then X is not methoxy and R.sup.3 is not methyl;
• and a pharmaceutically acceptable carrier or diluent.

A pharmaceutical compsition comprising a therapeutically effective amount of a compound represented by the formula:

• ##STR17## wherein A is ##STR18## and wherein R is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl or C.sub.2 -C.sub.10 alkynyl, each optionally substituted with at least one amino, acylamino, halo, trifluoromethyl, hydroxy, alkoxy, alkyl, acyl, aryl, heteroaryl, substituted heteroaryl group or combination thereof;
• R.sup.1 and R.sup.2 are each independently H or C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl wherein the alkyl, alkenyl or alkynyl group or combination thereof is optionally substituted with halo or alkoxy;
• X is A, R.sup.4 or OR.sup.5 wherein
• R.sup.3 and R.sup.5 each is independently H, C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl or heteroaralkyl;
• R.sup.4 is C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl or heteroaralkyl;
• or both X and OR.sup.3 are A;
• and a pharmaceutically acceptable carrier or diluent.