Water insoluble derivatives of hyaluronic acid
AssigneeGenzyme Corporation
InventorsJames W. Burns, Robert Miller
Life of this patent
Estimating the term…
Abstract
A water insoluble, biocompatible composition that includes the reaction product of a polyanionic polysaccharide and an activating agent.
Claims21
A method for making a water insoluble biocompatible composition, said method consisting essentially of combining, in an aqueous solution, a polyanionic polysaccharide selected from the group consisting of carboxymethylcellulose and carboxymethylamylose, and a carbodiimide under conditions sufficient to form said composition, wherein the reaction is carried out at a pH below 8.0, and the molar ratio of polysaccharide to carbodiimide is 1 mole of carboxyl groups of polysaccharide to at least about 4 moles of carbodiimide.
Dependencies are inferred from the claim text.