Dehydrodidemnin B as an L-type calcium channel enhancer
OwnerWilliam J. Crumb, Glynn T. Fairclothinventors
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Abstract
This invention relates to a new use discovered for the compound known as Aplidine (dehydrodidemnin B) which has the following structure: Aplidine has been found to be a potent L-type calcium channel enhancer in the human heart. This effect makes Aplidine a very useful drug for the treatment of congestive heart failure, as well as useful for the treatment of atrial fibrillation.
Claims22
A method of producing a cardiotonic effect in a patient in need thereof, which comprises administering to said patient the compound dehydrodidemnin B or a pharmaceutically acceptable salt thereof in an amount effective to produce said cardiotonic effect.
A method of treating congestive heart failure in a mammal in need thereof comprising administering to said mammal an effective amount of a compound of the formula:
- ##STR2## or pharmaceutically acceptable salts thereof.
A method for producing cardiotonic activity comprising administering to a patient in need of treatment an effective cardiotonic amount of a pharmaceutical composition comprising dehydrodidemnin B and a pharmaceutically acceptable carrier, diluent or excipient.
A method for treating congestive heart failure comprising administering to a patient in need of treatment an effective amount of a pharmaceutical composition comprising dehydrodidemnin B and a pharmaceutically acceptable carrier, diluent or excipient.
A method for prolonging the survival from heart failure in a patient suffering from cardiac insufficiency by administering to said patient the compound dehydrodidemnin B or a pharmaceutically acceptable salt thereof in an amount effective to improve cardiac contractile function in said patient.
A method for prolonging the survival from heart failure in a patient suffering from insufficient cardiac contractile function comprising administering to said patient the compound dehydrodidemnin B or a pharmaceutically acceptable salt thereof in an amount sufficient to produce a cardiovascular agonist effect in said patient.
A method of producing a Class III antiarrhythmic effect for the treatment of atrial arrhythmias in a patient in need of such treatment, comprising administering to said patient the compound dehydrodidemnin B or a pharmaceutically acceptable salt thereof in an amount sufficient to produce a cardiovascular agonist effect in said patient.
Dependencies are inferred from the claim text.