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US 6,030,833 AGranted
Transgenic swine and swine cells having human HLA genes
AssigneeThe General Hospital Corporation
InventorsJoerg Seebach, David H. Sachs, Harout DerSimonian, Christian LeGuern
Life of this patent
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Abstract
A genetically engineered swine cell having a transgene encoding a human HLA protein.
Claims14
An isolated genetically engineered swine cell which includes one or more of a human HLA A, HLA B, HLA C, or HLA G transgene, wherein expression of said transgene minimizes human NK cell mediated attack upon the swine cell.
An isolated nucleic acid including a swine promoter operably linked to a human HLA A, HLA B, HLA C, or HLA G gene.
Dependencies are inferred from the claim text.