Non-cytotoxic polyurethane medical items
AssigneeHospal Industrie
InventorsGuy Esposito, Pierre-Yves Herze
Life of this patent
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Abstract
Medical article of manufacture comprising compositions, comprising: at least one polyisocyanate, preferably a non-aromatic polyisocyanate, in the monomer or prepolymer state; at least one polypol; and at least one organic compound comprising one or more phosphite functional groups, in the proportion of at least 1% by weight with respect to the total weight of the polyol or polyols, this organic compound being, in addition, non-aromatic and the carrier of at least one free hydroxyl group capable of reacting with an isocyanato group; and, if appropriate, at least one catalyst of the polymerization reaction of a polyisocyanate and of a polyol.
Claims13
In an article of manufacture comprising a polyurethane potting body in contact with a flat-membrane or hollow-fiber medical exchanger, the improvement wherein the potting body is obtained from polyurethane-generating compositions comprising:
- at least one polyisocyanate, in the monomer or prepolymer state;
- at least one polyol;
- at least one organic compound comprising one or more phosphite functional groups, in the proportion of at least 1% by weight with respect to the total weight of the polyol or polyols, said organic compound being non-aromatic and having at least one free hydroxyl group capable of reacting with an isocyanato group;
- and
- optionally, at least one catalyst of the polymerization reaction of a polyisocyanate and of a polyol.
A process for reducing the cytotoxicity of polyurethane medical articles after sterilization or disinfection by an oxidizing process, comprising providing a polyurethane-generating composition prepared from at least one polyisocyanate, in the monomer or prepolymer state, from at least one polyol, from at least one organic compound comprising one or more phosphite functional groups, in the proportion of at least 1% by weight with respect to the total weight of the polyol or polyols, said organic compound being, in addition, non-aromatic and having at least one free hydroxyl group capable of reacting with an isocyanato group, and, optionally, from at least one catalyst of the polymerization reaction of a polyisocyanate and of a polyol, as a component of said medical article, and sterilizing or disinfecting by an oxidation process said article.
Dependencies are inferred from the claim text.