Bioresorbable ceramic composites
AssigneeEtex Corporation
InventorsDosuk D. Lee, Christian Rey, Maria Aiolova
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Abstract
A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intramuscular or subcutaneous site, resorption of at least 1 g of the material is complete within one year. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable.
Claims32
A composite material, comprising:
- (a) a strongly resorbable, poorly crystalline apatitic (PCA) calcium phosphate cement having an x-ray diffraction pattern similar to naturally occurring bone made by the process comprising:
- providing a paste comprised of amorphous calcium phosphate and water, whereby the paste hardens and converts to the poorly crystalline apatitic calcium phosphate,
- the poorly crystalline apatitic calcium phosphate characterized in that, at least about 80% is resorbed within one year when 1 g of the PCA calcium phosphate is placed in a rat intramuscular site;
- and
- (b) a biocompatible supplemental material, said material in intimate contact with the poorly crystalline material and present in an amount effective to impart a selected characteristic to the composite.
A method for embedding a supplemental material at a bony site, comprising:
- providing a strongly bioresorbable, poorly crystalline apatitic calcium phosphate having an x-ray diffraction pattern similar to naturally occurring bone, the poorly crystalline apatitic calcium phosphate made by the process comprising:
- providing a paste comprised of amorphous calcium phosphate and water, whereby the paste hardens and converts to the poorly crystalline apatitic calcium phosphate,
- said poorly crystalline apatitic calcium phosphate material in intimate contact with a non-resorbable or weakly resorbable supplemental material to form a composite;
- introducing the composite to a bony site, whereby the poorly crystalline apatitic calcium phosphate is resorbed and ossified and the non-resorbable supplemental material remains at the bone site.
A method for embedding a supplemental material at a bony site, comprising:
- providing a paste comprised of amorphous calcium phosphate and water, whereby the paste hardens and converts to a poorly crystalline apatitic calcium phosphate,
- the poorly crystalline apatitic calcium phosphate having an x-ray diffraction pattern similar to naturally occurring bone, said poorly crystalline apatitic calcium phosphate material in intimate contact with a non-resorbable or weakly resorbable supplemental material to form a composite;
- and
- introducing the composite to a bony site, whereby the poorly crystalline apatitic calcium phosphate is resorbed and ossified and the non-resorbable supplemental material remains at the bone site.
Dependencies are inferred from the claim text.