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US 6,027,729 AGranted
NANBV Diagnostics and vaccines
AssigneeChiron Corporation
InventorsMichael Houghton, Qui-Lim Choo, George Kuo
Life of this patent
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AssigneeChiron Corporation
InventorsMichael Houghton, Qui-Lim Choo, George Kuo
Estimating the term…
A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicates that HCV may be related to the Flaviviruses. The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBH agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.
An isolated polypeptide comprising an amino acid sequence of at least 12 contiguous amino acids encoded by a hepatitis C virus (HCV) genome.
An isolated polypeptide comprising an amino acid sequence of at least 8 contiguous amino acids encoded by a hepatitis C virus-1 (HCV-1) genome.
An isolated polypeptide comprising an amino acid sequence of at least 12 contiguous amino acids encoded by a hepatitis C virus (HCV) genome, wherein said polypeptide is immunologically reactive with an anti-HCV antibody.
An isolated polypeptide comprising an amino acid sequence of at least 8 contiguous amino acids encoded by a hepatitis C virus-1 (HCV-1) genome, wherein said polypeptide is immunologically reactive with an anti-HCV antibody.
An isolated polypeptide comprising an amino acid sequence of at least 8 contiguous amino acids encoded by a cDNA insert in the .lambda.gt-11 cDNA library deposited as ATCC No. 40394, wherein said polypeptide is immunologically reactive with an anti-HCV antibody.
An isolated polypeptide comprising a contiguous amino acid sequence encoded by a hepatitis C virus (HCV) genome, wherein said amino acid sequence is selected from the following group:
Dependencies are inferred from the claim text.