Polynucleotides encoding human G-protein chemokine receptor HDGNR10
AssigneeHuman Genome Sciences, Inc.
InventorsYi Li, Steven M. Ruben
Life of this patent
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Abstract
Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
Claims19
An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding amino acids 1 to 352 of SEQ ID NO:2;
- (b) a polynucleotide encoding amino acids 2 to 352 of SEQ ID NO:2;
- (c) a polynucleotide encoding a polypeptide having the amino acid sequence encoded by the cDNA contained in ATCC Deposit No. 97183;
- (d) the complement of (a);
- (e) the complement of (b);
- and
- (f) the complement of (c).
An isolated nucleic acid molecule comprising a polynucleotide encoding at least 50 contiguous amino acids of SEQ ID NO:2.
An isolated nucleic acid molecule which maps to the same chromosome location as SEQ ID NO:1.
Dependencies are inferred from the claim text.