Solubility parameter based drug delivery system and method for altering drug saturation concentration
AssigneeNoven Pharmaceuticals, Inc.
InventorsJesus Miranda, Steven Sablotsky
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Abstract
A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, soluble polyvinylpyrrolidone can be used to prevent crystallization of the drug, without affecting the rate of drug delivery from the pressure-sensitive adhesive composition.
Claims66
A transdermal drug delivery system comprising a pressure-sensitive adhesive composition, wherein said composition comprises a blend of (1) a synthetic elastomeric polymer;
- (2) a soluble PVP and (3) at least one drug.
A transdermal drug delivery system comprising a pressure-sensitive adhesive composition, wherein said composition comprises a blend of (1) a synthetic elastomeric polymer, (2) a polyacrylate polymer, (3) a soluble PVP and (4) at least one drug.
Dependencies are inferred from the claim text.