Use of hyaluronic acid and forms to prevent arterial restenosis
AssigneeHyal Pharmaceutical Corporation
InventorsRudolf Edgar Falk, Samuel Simon Asculai, Eva Anne Turley
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Abstract
A method is provided of inhibiting the narrowing of the vascular tubular walls of an animal by the proliferation of endothelial cells in the area of trauma after the vascular tubular walls have been traumatized, the method comprising the administration of a therapeutically effective non-toxic amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof to the animal to inhibit the narrowing of the vascular tubular walls by the proliferation of endothelial cells into the area of trauma.
Claims20
A method of inhibiting the narrowing of the vascular tubular walls of an animal by the proliferation of endothelial cells in the area of trauma after the vascular tubular walls have been traumatized, the method comprising the administration of a therapeutically effective non-toxic amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof, and a therapeutically effective amount of an agent selected from the group consisting of a non-steroidal anti-inflammatory drug (NSAID), Vitamin C, a stenosis inhibiting drug, an anti-oxidant, a free radical scavenger and combinations thereof for enhancing the effect of the form of hyaluronic acid administered in the inhibition of the narrowing of the tubular walls to the animal to inhibit the narrowing of the vascular tubular walls by the proliferation of the endothelial cells on the area of trauma, and wherein the molecular weight of the form of hyaluronic acid is less than 750,000 daltons and greater than 150,000 daltons.
A method of inhibiting arterial restenosis of the arterial wall by the proliferation of endothelial cells on the inner wall of the artery after balloon angioplasty in a human, the method comprising the administration of a therapeutically effective non-toxic amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid, pharmaceutically acceptable salts thereof and combinations thereof, a therapeutically effective amount of an agent selected from the group consisting of a non-steroidal anti-inflammatory drug (NSAID), Vitamin C, a stenosis inhibiting drug, an anti-oxidant, a free radical scavenger and combinations thereof for enhancing the effect of the form of hyaluronic acid administered in the inhibition of the narrowing of the tubular walls to the human to inhibit arterial restenosis by the proliferation of endothelial cells on the inner wall of the artery, and wherein the molecular weight of the form of hyaluronic acid is less than 750,000 daltons and greater than 150,000 daltons.
A method of inhibiting arterial restenosis of the arterial wall by the proliferation of endothelial cells on the area of trauma after balloon angioplasty, the method comprising the administration of a therapeutically effective non-toxic amount of hyaluronic acid and/or pharmaceutically acceptable salts thereof whose molecular weight is less than 750,000 daltons and greater than 150,000 daltons, and a therapeutically effective amount of an agent selected from the group consisting of a non-steroidal anti-inflammatory drug (NSAID), Vitamin C, a stenosis inhibiting drug, an anti-oxidant, a free radical scavenger and combinations thereof for enhancing the effect of the form of hyaluronic acid administered in the inhibition of the narrowing of the tubular walls to inhibit arterial restenosis by the proliferation of the endothelial cells on the area of trauma.
A pharmaceutical composition comprising together with diluents, adjuvants and other pharmaceutical carriers as desired;
- (1) an effective amount of a form of hyaluronic acid selected from the group consisting of hyaluronic acid, pharmaceutically acceptable salts thereof, and combinations thereof, and
- (2) an agent selected from the group consisting of a stenosis inhibiting drug, a non-steroidal anti-inflammatory drug (NSAID), Vitamin C, a free radical scavenger, and an anti-oxidant and combinations thereof, for inhibiting the narrowing of the vascular tubular walls of an animal by the build-up of endothelial cells on the vascular tubular walls after the tubular walls have been traumatized, the composition being characterized by an effective non-toxic amount of the form of hyaluronic acid being incorporated into the composition together with a therapeutically effective amount of agent (2), to inhibit tubular wall narrowing by the build-up of endothelial cells on the vascular tubular walls, wherein the effective amount of component (1) is between 10 mg to 3000 mg to prevent the narrowing of the tubular walls of the animal by the build-up of endothelial cells on the vascular tubular walls and wherein component (2) enhances the effect of component (1) in the prevention of the narrowing of the tubular walls by the build-up of endothelial cells on the vascular tubular walls, and wherein the molecular weight of component (1) is less than 750,000 daltons and greater than 150,000 daltons.
Dependencies are inferred from the claim text.