Back to results
US 6,022,538 AGranted
Method of treating malignancies
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsDaniela Santoli, Giovanni Rovera, Alessandra Cesano
Life of this patent
Estimating the term…
Abstract
A method of treating tumors which involves a synergistic combination of chemotherapy and cell therapy is provided. The method of the invention permits reduced amounts of chemotherapeutic agents to be administered, resulting in a reduction of the side effects often associated therewith.
Claims9
A method of treating cancer in a mammal comprising the steps of
- administering to the mammal a course of therapy with an effective amount of a chemotherapeutic agent selected from the group consisting of adriamycin and cisplatin;
- and
- administering a course of therapy with an effective amount of TALL-104 cells ATCC Accession No. CRL11386, which cells have been modified by stimulation in vitro by treatment with a cytokine and gamma irradiation at a dose suitable to irreversibly arrest cell proliferation but not interfere with the cytotoxic activity of the cells, said modified cells characterized by irreversibly arrested cell proliferation and non-MHC restricted cytotoxic activity said TALL-104 administering step occurring during or after said administration of said chemotherapeutic agent.
Dependencies are inferred from the claim text.