Carbamoyloxy derivatives of mutiline and their use as antibacterials
OwnerJeremy David Hinks, Andrew Kenneth Takle +1inventors
InventorsJeremy David Hinks, Andrew Kenneth Takle, Eric Hunt
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Abstract
Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R.sup.1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the treatment of bacterial infections. ##STR1##
Claims10
A compound of formula (1A) or a pharmaceutically acceptable salt or derivative thereof ##STR5## in which Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted.
A compound of general formula (3), or a pharmaceutically acceptable salt or derivative thereof ##STR6## in which:
- R.sup.1 is vinyl or ethyl;
- R.sup.2 and R.sup.3 are the same or different groups selected from hydrogen;
- a straight or branch chained, saturated or unsaturated, optionally substituted, C.sub.1 to C.sub.6 hydrocarbon group;
- a saturated or unsaturated, optionally substituted, C.sub.3 to C.sub.8 cyclic hydrocarbon group;
- an optionally substituted heterocyclic group;
- an optionally substituted aryl group;
- or together form an optionally substituted cyclic group of 3 to 8 ring atoms, optionally containing one additional heteroatom selected from N, O and S, and optionally fused to a hydrocarbon ring, a heterocyclic group or an aromatic group;
- or
- R.sup.2 is one of the above monovalent groups and R.sup.3 is a group selected from SO.sub.2 R.sup.4, COR.sup.5, OR.sup.5 and NR.sup.6 R.sup.7 where
- R.sup.4 is selected from a straight or branch chained, saturated or unsaturated, optionally substituted, C.sub.1 to C.sub.6 hydrocarbon group;
- a saturated or unsaturated, optionally substituted, C.sub.3 to C.sub.8 cyclic hydrocarbon group;
- an optionally substituted heterocyclic group;
- an optionally substituted aryl group;
- an optionally substituted C.sub.1 to C.sub.6 alkylamino group;
- and an optionally substituted arylamino group;
- R.sup.5 is selected from hydrogen;
- a straight or branch chained, saturated or unsaturated, optionally substituted, C.sub.1 to C.sub.6 hydrocarbon group;
- a saturated or unsaturated, optionally substituted, C.sub.3 to C.sub.8 cyclic hydrocarbon group;
- an optionally substituted heterocyclic group;
- and an optionally substituted aryl group;
- R.sup.6 and R.sup.7 are the same or different groups selected from hydrogen;
- a straight or branch chained, saturated or unsaturated, optionally substituted, C.sub.1 to C.sub.6 hydrocarbon group;
- a saturated or unsaturated, optionally substituted, C.sub.3 to C.sub.8 cyclic hydrocarbon group;
- an optionally substituted heterocyclic group, and an optionally substituted aryl group;
- or together form an optionally substituted cyclic group of 3 to 8 ring atoms, optionally containing one additional heteroatom selected from N, O and S, and optionally fused to a hydrocarbon ring, a heterocyclic group or an aromatic group.
Dependencies are inferred from the claim text.