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US 6,020,208 AGranted
Systems for surface-enhanced affinity capture for desorption and detection of analytes
AssigneeBaylor College of Medicine
InventorsT. William Hutchens, Tai-Tung Yip
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Abstract
This invention is directed to systems containing probes for presenting an analyte to an energy source for desorption in methods of analytic detection, such as mass spectrometry. The probes have an immobilized affinity reagent which binds the analyte on their presenting surface.
Claims54
A system for detecting an analyte comprising:
- a removably insertable probe having a surface for presenting the analyte to an energy source that emits energy capable of desorbing the analyte from the probe surface, and an immobilized affinity reagent on the probe surface capable of binding the analyte;
- an energy source that directs energy to the probe surface for desorbing the analyte;
- and
- a detector in communication with the probe surface that detects the desorbed analyte.
1 more element
A method for detecting an analyte comprising the steps of:
- a) providing a system comprising:
- (1) a removably insertable probe having a surface for presenting the analyte to an energy source that emits energy capable of desorbing the analyte from the probe, and an immobilized affinity reagent on the probe surface capable of binding the analyte;
- (2) an energy source that directs energy to the probe surface for desorbing the analyte;
- and
- (3) a detector in communication with the probe surface that detects the desorbed analyte;
- b) desorbing at least a portion of the analyte from the probe surface by exposing the analyte to energy from the energy source;
- and
- c) detecting the desorbed analyte with the detector.
5 more elements
Dependencies are inferred from the claim text.