Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases

A compound of the formula:

• ##STR354## wherein:
• X is independently selected from the group consisting of, --Br, --Cl, --F, --I, --CF.sub.3, alkyl, --OH, --OCF.sub.3, --O-alkyl, and --O-acyl;
• R.sub.1 is independently selected from the group consisting of --H, lower alkyl, and --O-acyl;
• R.sub.2 is independently selected from the group consisting of --H, alkyl, and hydroxyalkyl, or both R.sub.2 s together are imino;
• R.sub.4 is phenoxy which is optionally substituted with --F, --Cl, --Br, --I, --CF.sub.3 alkyl, --OH, --OCF.sub.3 --O-alkyl, or --O-acyl;
• provided that when X is H, then R.sub.4 is substituted with meta-fluoro, meta-chloro, ortho-fluoro, ortho-chloro, meta-methyl, ortho-OH, or meta-OH;
• and
• m is independently an integer from 1 to 5;
• and pharmaceutically acceptable salts and complexes thereof.

A compound of the formula:

• ##STR355## wherein:
• X is independently selected from the group consisting of --F, --Cl, --Br, --I, --CF.sub.3 alkyl, --OH, --OCF.sub.3, --O-alkyl, and --O-acyl;
• R.sub.1 is independently selected from the group consisting of lower alkyl, and --O-acyl;
• R.sub.2 is independently selected from the group consisting of --H, lower alkyl, and hydroxyalkyl, or both R.sub.2 s together are imino;
• R.sub.3 is selected from the group consisting of methyl and ethyl;
• R.sub.4 is phenoxy which is optionally substituted with --F, --Cl, --Br, --I, --CF.sub.3, alkyl, --OH, --OCF.sub.3, --O-alkyl, or --O-acyl;
• provided that when X is para-fluoro, R.sub.4 is not meta-CF.sub.3 -substituted phenoxy;
• and m is independently an integer from 1 to 5;
• and pharmaceutically acceptable salts and complexes thereof.

A compound of the formula:

• ##STR356## wherein:
• (X)m is selected from the group consisting of meta-fluoro, meta-chloro, ortho-O-lower alkyl, ortho-methyl, ortho-fluoro, ortho-chloro, meta-O-lower alkyl, meta-methyl, ortho-OH, and meta-OH;
• R.sub.1 is H;
• R.sub.2 is H;
• R.sub.3 is selected from the group consisting of methyl and ethyl;
• R.sub.4 is phenoxy which is optionally substituted with --F, --Cl, --Br, --I, --CF.sub.3, alkyl, --OH, --OCF.sub.3, --O-alkyl, or --O-acyl;
• and pharmaceutically acceptable salts and complexes thereof.

A compound of the formula:

• ##STR357## wherein:
• X is independently selected from the group consisting of --H, --Br, --Cl, --F, --I, --CF.sub.3, alkyl, --OH, --OCF.sub.3, --O-alkyl, and --O-acyl;
• R.sub.1 is independently selected from the group consisting of --H, alkyl, hydroxyalkyl, --OH, --O-alkyl, and --O-acyl;
• R.sub.2 is independently selected from the group consisting of --H, alkl, and hydroxyalkyl, or both R.sub.2 s together are imino;
• R.sub.3 is independently selected from the group consisting of --H, methyl, and ethyl;
• R.sub.4 is phenylthio which is optionally substituted with --F, --Cl, --Br, --I, --CF.sub.3, alkyl, --OH, --OCF.sub.3, --O-alkyl, or --O-acyl;
• and
• m is independently an integer from 0 to 5;
• and pharmaceutically acceptable salts and complexes thereof.