Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
AssigneeTrimeris, Inc.
InventorsShawn O'Lin Barney, Dennis Michael Lambert, Stephen Robert Petteway, Alphonse J. Langlois
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Abstract
The present invention relates to peptides which exhibit antifusogenic and antiviral activities. The peptides of the invention consist of a 16 to 39 amino acid region of a simian immunodeficiency virus (SIV) protein. These regions were identified through computer algorithms capable of recognizing the ALLMOTI5, 107.times.178.times.4, or PLZIP amino acid motifs. These motifs are associated with the antifusogenic and antiviral activities of the claimed peptides.
Claims28
An isolated peptide consisting of an amino acid sequence of a 16 to 39 amino acid region of an SIV retrovirus protein, wherein said region is identified by an ALLMOTI5, 107.times.178.times.4, or PLZIP sequence search motif, said peptide further consisting of an amino terminal X, and a carboxy terminal Z in which:
- X comprises an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group, a hydrophobic group, or a macromolecular carrier group;
- and
- Z comprises a carboxyl group, an amido group, a hydrophobic group, or a macromolecular carrier group.
A peptide having the formula
- __________________________________________________________________________ X-TWQEWERKVDFLEENITALLEEAQIQQEKNMYELQKLNSWDVFGNWF-Z (SEQ ID NO. 138), X-TWQEWERKVDFLEENITALLEEAQIQQEKNMYELQ-Z (SEQ ID NO. 139), - X-WQEWERKVDFLEENITALLEEAQIQQEKNMYELQK-Z (SEQ ID NO. 140), - X-QEWERKVDFLEENITALLEEAQIQQEKNMYELQKL-Z (SEQ ID NO. 141), - X-EWERKVDFLEENITALLEEAQIQQEKNMYELQKLN-Z (SEQ ID NO. 142), - X-WERKVDFLEENITALLEEAQIQQEKNMYELQKLNS-Z (SEQ ID NO. 143), - X-ERKVDFLEENITALLEEAQIQQEKNMYELQKLNSW-Z (SEQ ID NO. 144), - X-RKVDFLEENITALLEEAQIQQEKNMYELQKLNSWD-Z (SEQ ID NO. 145), - X-KVDFLEENITALLEEAQIQQEKNMYELQKLNSWDV-Z (SEQ ID NO. 146), - X-VDFLEENITALLEEAQIQQEKNMYELQKLNSWDVF-Z (SEQ ID NO. 147), - X-DFLEENITALLEEAQIQQEKNMYELQKLNSWDVFG-Z (SEQ ID NO. 148), or - X-FLEENITALLEEAQIQQEKNMYELQKLNSWDVFGN-Z (SEQ ID NO. 149) __________________________________________________________________________
- in which:
- amino acid residues are presented by the single-letter code;
- X comprises an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group, a hydrophobic group, or a macromolecular carrier group;
- and
- Z comprises a carboxyl group, an amido group, a hydrophobic group, or a macromolecular carrier group.
The peptide of claim wherein the peptide has the formula
- X-VDFLEENITALLEEAQIQQEKNMYELQKLNSWDVF-Z (SEQ ID NO. 147).
Dependencies are inferred from the claim text.