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AssigneeUnited States Surgical Corporation
InventorsTimothy McPherson, Kinam Park, Seongbong Jo
Estimating the term…
Methods for grafting unmodified PEO or any other water-soluble polymers to the surfaces of metals and glasses to form biocompatible surfaces having low protein affinity is provided. One technique includes the steps of: (a) providing a support member having a plurality of hydroxyl or oxide groups attached to a surface of said support member; (b) exposing said surface to a silane coupling agent to cause the silane coupling agent to form a silane layer that is covalently bound to the surface wherein the silane layer comprises a plurality of vinyl groups; and (c) exposing the silane layer to a hydrophilic polymer and causing the silane layer to react with the hydrophilic polymer to covalently bond to the silane layer. Exposure of the silane layer to .gamma.-radiation to induce grafting with low radiation to induce grafting of the hydrophilic polymer to the silane layer. Another technique comprises grafting a silylated hydrophilic polymer or chain having a hydrophobic domain directly to the metal or inorganic surface.
A method of grafting hydrophilic polymers to a surface of an article comprising the steps of:
A method of grafting hydrophilic polymers to a surface of an article comprising the steps of:
A device having a biocompatible surface that has hydrophilic polymers grafted onto the surface and having been fabricated by a process comprising the steps of:
A method of grafting hydrophilic polymers to a surface of an article comprising the steps of:
A device having a biocompatible surface that has hydrophilic polymers grafted onto the surface and having been fabricated by a process comprising the steps of:
Dependencies are inferred from the claim text.