Vaccine
AssigneeSmithKline Beecham Biologicals s.a.
InventorsJean Petre, Pierre Hauser
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Abstract
Stable and effective multivalent vaccine compositions comprising Hepatitis B surface antigen (HBsAg) are described wherein the HBsAg component is stable for one week at 37.degree. C. and is highly immunogenic, for example when the vaccine is administered to infants. The compositions typically comprise HBsAg adsorbed to aluminium phosphate and other antigens, especially those suitable for use in a paediatric vaccine, adsorbed to aluminium phosphate or aluminium hydroxide. Methods for preparing the vaccines and the use of aluminium phosphate to stabilise HBsAg in a multivalent vaccine formulation are also described.
Claims20
A combined vaccine composition comprising Hepatitis B surface antigen (HBsAg) and a number (n) of other antigens against one or more of the following pathogens:
- diphtheria, tetanus, pertussis, polio, Haemophilus influenzae b, Hepatitis A, meningitis A, meningitis B, meningitis C, and otitis media, in combination with an adjuvant comprising one or more aluminum salts and in which the adjuvant used to adsorb the HBsAg is aluminum phosphate, with the proviso that when n is 1 the other antigen is not an antigen against hepatitis A.
A stable and effective combined vaccine composition directed to the prevention of more than two diseases comprising HBsAg and at least two other antigens against two or more of the following pathogens:
- diphtheria, tetanus, pertussis, polio, Haemophilus influenzae b, Hepatitis A, meningitis A, meningitis B, meningitis C, and otitis media, in which the HBsAg is adsorbed to aluminum phosphate.
A method of preparing a stable and effective vaccine composition wherein the method comprises admixing aluminium phosphate--adsorbed to HBsAg, with one or more antigens adsorbed to aluminium hydroxide or aluminium phosphate, with the proviso that when one antigen is used it is not an antigen providing immunity against Hepatitis A infection and recovering said stable and effective combination vaccine.
Dependencies are inferred from the claim text.