Process for preparing .beta.-lactam halide compound
AssigneeOtsuka Kagaku Kabushiki Kaisha
InventorsSigeru Torii, Hideo Tanaka, Michio Sasaoka, Yutaka Kameyama, Daisuke Suzuki
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AssigneeOtsuka Kagaku Kabushiki Kaisha
InventorsSigeru Torii, Hideo Tanaka, Michio Sasaoka, Yutaka Kameyama, Daisuke Suzuki
Estimating the term…
A process for preparing a .beta.-lactam halide compound represented by the formula (2) characterized by halogenating the allenyl group of an allenyl .beta.-lactam compound represented by the formula (1) with a cupric halide and a metal halide to obtain the .beta.-lactam halide compound ##STR1## wherein R.sup.1 is a hydrogen atom or amino or protected amino, R.sup.2 is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, or lower alkyl having a hydroxyl group or protected hydroxyl group as a substituent, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, and R.sup.4 is a hydrocarbon group which may have a substituent, or the group --S--S(O)n-Ar, n being 0 to 2, Ar being aryl which may have a substituent ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as defined above, X and Y are each halogen atom.
A process for preparing a .beta.-lactam halide compound represented by the formula 2A ##STR8## comprising halogenating the allenyl group of an allenyl .beta.-lactam compound of formula (1) ##STR9## with a cupric (II) halide and a metal halide to obtain the .beta.-lactam halide compound, wherein R.sup.1 is an amino or a protected amino, R.sup.2 is a hydrogen atom, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, and R.sup.4 is selected from the group consisting of --CH.sub.2 OSO.sub.2 CH.sub.3 and --CH.sub.2 OSO.sub.2 CF3 wherein formula 2A has R.sup.1, R.sup.2, R.sup.3, and R.sup.4 as defined above, and X and Y are each halogen atoms.
Dependencies are inferred from the claim text.