Combinations for diabetes
AssigneeWarner-Lambert Company
InventorRandall Wayne Whitcomb
Life of this patent
Estimating the term…
Abstract
Combinations of a glitazone antidiabetic agent and a biguanide antidiabetic agent, and optionally a sulfonylurea antidiabetic agent, are useful for treating diabetes mellitus and improving glycemic control.
Claims16
A composition comprising from about 3 mg to about 250 mg of a sulfonylurea antidiabetic agent, from about 5 mg to about 2500 mg of a glitazone antidiabetic agent selected from troglitazone, rosiglitazone and pioglitazone, and from about 300 mg to about 2000 mg of a biguanide antidiabetic agent, said amounts being synergistic in the treatment of non-insulin dependent diabetes mellitus.
A synergistic composition comprising from about 100 mg to about 1000 mg of troglitazone, from about 3 mg to about 250 mg of glyburide, and from about 300 mg to about 2000 mg of metformin.
A synergistic composition comprising from about 5 mg to about 10 mg of rosiglitazone, from about 3 mg to about 250 mg of a sulfonylurea, and from about 300 mg to about 2000 mg of metformin.
A synergistic composition comprising from about 50 mg to about 200 mg of pioglitazone, from about 3 mg to about 250 mg of a sulfonylurea, and from about 300 mg to about 2000 mg of metformin.
A method of treating diabetes by administering to a patent in need of treatment from about 3 mg to about 250 mg of a sulfonylurea antidiabetic agent in combination with from about 5 mg to about 2500 mg of a glitazone antidiabetic agent selected from troglitazone, rosiglitazone and pioglitazone and from about 300 mg to about 2000 mg of a biguanide antidiabetic agent, wherein said amounts are synergistic for the treatment of non-insulin dependent diabetes mellitus.
A method of treating diabetes by administering to a patient in need of treatment from about 5 mg to about 10 mg of rosiglitazone together with from about 300 mg to about 2000 mg of metformin and from about 3 mg to about 250 mg of a sulfonylurea, wherein said amounts are synergistic for the treatment of non-insulin dependent diabetes mellitus.
A method of treating diabetes by administering to a patient in need of treatment from about 100 mg to about 1000 mg of troglitazone together with from about 300 mg to about 2000 mg of metformin and from about 3 mg to about 250 mg of a sulfonylurea, wherein said amounts are synergistic for the treatment of non-insulin dependent diabetes mellitus.
A method of treating diabetes by administering to a patient in need of treatment from about 50 mg to about 200 mg of pioglitazone together with from about 300 mg to about 2000 mg of metformin and from about 3 mg to about 250 mg of a sulfonylurea, wherein said amounts are synergistic for the treatment of non-insulin dependent diabetes mellitus.
Dependencies are inferred from the claim text.