US 6,010,905 A · Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells

Abstract

The present invention relates to methods of increasing the antigen presenting ability of monocytes by contacting them with an agent which increases the intracellular calcium level. Methods of obtaining the monocytes are also disclosed. In addition, the present invention relates to methods of inducing bone marrow progenitor cells and endothelial cells to express molecules involved in generating immune responses. Methods of modulating the expression of molecules involved in generating immune responses are also disclosed, as are methods of treating cancer and leukemia.

Claims32

Dependent claims

A method of increasing the antigen presenting ability of monocytes comprising:

obtaining a population of cells from a subject comprising monocytes in order to increase the antigen presenting ability of said monocytes;
and contacting said monocytes with an agent which elevates the intracellular calcium concentration to a level sufficient to increase the antigen presenting ability of said monocytes.

Dependencies are inferred from the claim text.

Facts

Application

08/885,671Filed 30 Jun 1997 · continuation in part

Priority

27 Jan 1995

Granted

4 Jan 2000

Term ends

Not estimatedThe source records don’t support an estimate.

Classification19 codes

C12N 5/0694
Tumour cells; Cancer cells: cells of blood, e.g. leukemia cells, myeloma cells
A61K 40/19
Characterised by the cell type used: dendritic cells
A61K 40/24
Characterised by the effect or the function of the cells: antigen-presenting cells [APC]
A61K 40/4274
Cancer antigens: prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid…

Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells

Life of this patent

Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells

Life of this patent

Abstract

Claims32