Polypeptides p57 or p9.5 of Borna disease virus and their use for diagnosis and immunization
OwnerJurgen A. Richtinventor
Life of this patent
Estimating the term…
Abstract
The invention involves polypeptides which correspond to amino acid sequences of protein p57 or protein p9.5 of Borna disease virus. These polypeptides, as well as DNA and RNA fragments are used in test kits and vaccines.
Claims13
A method of detecting antibody indicative of infection by Borna disease virus, comprising contacting a sample with a polypeptide comprising the sequence of the C-terminal region of p57, under conditions for antibody binding, and detecting antibodies bound to said polypeptide.
A test kit useful in determining an antibody directed against Borna disease virus, comprising a polypeptide comprising the sequence of the C-terminal region of p57 and a labeled substance specific for complexes of said antibody and said polypeptide.
An isolated polypeptide comprising the sequence of SEQ ID NO. 1 or SEQ ID NO. 3.
An isolated polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:
- 3.
A method for inducing antibodies to a Borna Disease Virus in a subject comprising the step of immunizing the subject with a composition comprising a polypeptide consisting of the sequence set forth in SEQ ID NO:
- 3 fused to a non-BDV polypeptide in an amount sufficient to induce antibody production in said subject.
Dependencies are inferred from the claim text.