Use of GLP-1 or analogs to abolish catabolic changes after surgery
AssigneeEli Lilly and Company
InventorSuad Efendic
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Abstract
This invention provides a method of attenuating post-surgical catabolic changes and hormonal responses to stress. GLP-1, a GLP-1 analog, or a GLP-1 derivative, is administered at a dose effective to normalize blood glucose.
Claims13
A method of attenuating post-surgical catabolic changes and insulin resistance, comprising, administering to a patient in need thereof a compound selected from the group consisting of GLP-1, GLP-1 analogs, GLP-1 derivatives, and pharmaceutically-acceptable salts thereof.
A method of attenuating post-surgical catabolic changes and hormonal responses to stress, comprising, administering to a patient in need thereof a compound that exerts insulinotropic activity by interacting with the same receptor, or receptors, with which GLP-1, GLP-1 analogs, and GLP-1 derivatives interact in exerting their insulinotropic activity.
A method of attenuating post-surgical catabolic changes and hormonal responses to stress, comprising, administering a compound that enhances insulin sensitivity by interacting with the same receptor, or receptors, with which GLP-1, GLP-1 analogs, and GLP-1 derivatives interact to enhance insulin sensitivity.
Dependencies are inferred from the claim text.