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US 6,005,079 AGranted
Immunoglobulins devoid of light chains
AssigneeVrije Universiteit Brussels
InventorsCecile Casterman, Raymond Hamers
Life of this patent
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Abstract
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.
Claims14
An immunoglobulin comprising two heavy polypeptide chains, each heavy chain containing a binding site specific for an antigen, said immunoglobulin containing a variable (V.sub.HH) region and a constant region, said constant region being devoid of fist constant domain C.sub.H 1, wherein the immunoglobulin is devoid of polypeptide light chains.
Dependencies are inferred from the claim text.