Use of von willebrand factor and pharmaceutical formulation
AssigneeImmuno Aktiengesellschaft
InventorsHans-Peter Schwarz, Peter Turecek, Johann Eibl
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Abstract
The invention relates to the use of von Willebrand Factor (vWF) with a prolonged biological half-life for the production of a preparation for stabilization of blood coagulation Factor VIII (FVIII:C) in a mammal. Additionally, a pharmaceutical preparation is provided comprising a biologically active FVIII:C/vWF complex with improved pharmokinetic properties, said complex containing a vWF with a prolonged biological half-life.
Claims15
A pharmaceutical preparation that increases the blood coagulation Factor VIII level consisting essentially of recombinantly-produced von Willebrand Factor (vWF), wherein the vWF (i) are multimers composed of singlets and (ii) have a prolonged in vivo circulatory half-life of more than 20 hours.
A pharmaceutical preparation that increases the blood coagulation Factor VIII level consisting essentially of recombinant von Willebrand Factor (vWF), wherein the vWF (i) are multimers composed of singlets and (ii) have a prolonged in vivo circulatory half-life of more than 20 hours and is obtainable by expressing in a mammalian cell a polynucleotide encoding vWF and a polynucleotide encoding a vWF-processing protease that is selected from the group consisting of furin and subtilisin-like enzymes.
A pharmaceutical preparation that increases the blood coagulation Factor VIII level, wherein the preparation consists essentially of recombinantly-produced von Willebrand Factor (vWF), wherein the vWF (i) are multimers composed of singlets and (ii) have an in vivo circulatory half-life of at least 30 hours.
A pharmaceutical preparation that increases the blood coagulation Factor VIII level in a mammal, wherein the preparation consists essentially of recombinantly-produced and proteolytically-processed von Willebrand Factor (vWF), (i) are multimers composed of singlets and (ii) have an in vivo circulatory half-life of at least 20 hours.
Dependencies are inferred from the claim text.