Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
AssigneeHoechst Marion Roussel, Inc.
InventorsWinton D. Jones, Fred L. Ciske, Robert J. Dinerstein, Keith A. Diekema
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Abstract
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).
Claims26
A compound of the formula:
- ##STR62## wherein:
- B is O or S;
- R.sup.4 is methyl, ethyl, n-propyl, or both R.sup.4 's can be combined to give pyrrolidinyl, piperidinyl or morpholino;
- R.sup.5 is C.sub.1 -C.sub.5 alkylene;
- V is hydrogen, methoxy, ethoxy, n-propoxy, butoxy;
- X is hydrogen, methoxy, ethoxy, n-propoxy, fluoro or chloro;
- Y is NH2, NHR, NHCOR, wherein R is C.sub.1 -C.sub.5 alkyl or phenyl;
- Z is hydrogen, C.sub.1 -C.sub.5 alkyl, fluoro or chloro, with the proviso that,
- Z may be present at the 1, 2, 3 or 4 position, and when present at the 1, 2 or 4 position, replaces Y, V or X, respectively;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.