Targeted polymerized liposomes for improved drug delivery
AssigneeMassachusetts Institute of Technology
InventorsRobert S. Langer, Hongming Chen
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Abstract
The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type in order to optimize the immune response to the encapsulated antigen or the efficacy of the encapsulated drug.
Claims18
A polymerized liposome suitable for oral delivery of a biologically active substance comprising a phospholipid bilayer having covalently bound phospholipids, an aqueous core and a bioactive molecule, wherein said liposome is modified to contain a targeting molecule which is selected from the group consisting of glycoproteins, lectins, carbohydrates, bacterial proteins and viral proteins.
A method of orally delivering molecules to an animal which comprises administering to said animal polymerized liposomes comprising a phospholipid bilayer having covalently bonded phospholipids, an aqueous core, a targeting molecule selected from the group consisting of glycolproteins, lectins, carbohydrates, bacterial proteins and viral proteins and a bioactive molecule.
Dependencies are inferred from the claim text.