Dust gun-aerosol generator and generation
AssigneeLovelace Respiratory Research Institute
InventorPer Magnus Gerde
Life of this patent
Estimating the term…
Abstract
An apparatus and method for aerosolizing and dispensing powders utilizing the forces of pressurizing and depressurizing gas loaded into powder agglomerates located in an enclosed powder chamber. Methods include administering peptides, genes, vitamins, and polymers into the peripheral lung. Also describes powder supply apparatus and method for single dose and repetitive applications.
Claims78
An apparatus for aerosolizing and dispensing powders, said apparatus comprising:
- a pressure chamber;
- at least one substantially straight ejecting conduit opening at an exit nozzle to ambient pressures;
- an enclosed powder chamber for loading with a pressurized gas and mixing the powder;
- and
- at least one pressure conduit connecting said pressure chamber and said powder chamber.
An apparatus for aerosolizing and dispensing powders, said apparatus comprising:
- a pressure chamber;
- an enclosed powder chamber for loading with a pressurized gas and mixing the powder;
- at least one pressure conduit connecting said pressure chamber and said powder chamber;
- and
- at least one substantially straight ejecting conduit of substantially uniform cross-section opening at an exit nozzle.
An apparatus for aerosolizing and dispensing powders, said apparatus comprising:
- a pressure chamber;
- at least one substantially straight ejecting conduit;
- an enclosed powder chamber for loading with a pressurized gas and mixing the powder, said powder chamber and said ejecting conduit meeting at an angle greater than 60 degrees from an axial extension from said ejecting conduit and a tangent of said powder chamber;
- and
- at least one pressure conduit connecting said powder chamber and said pressure chamber.
An apparatus for aerosolizing and dispensing powders, said apparatus comprising:
- a pressure chamber;
- at least one substantially straight ejecting conduit, of substantially uniform cross-section opening at an exit nozzle;
- an enclosed powder chamber for loading with a pressurized gas and mixing the powder;
- and
- at least one pressure conduit connecting said powder chamber and said pressure chamber;
- said exit nozzle and said ejecting conduit meeting at an angle at least 45 degrees from an axial extension of said ejecting conduit and a plane of said exit nozzle.
A method of generating a fine aerosol from a powder substance comprising the following steps:
- a) agitating and loading with a pressurized gas a powder in an enclosed powder chamber to create a pressurized suspension;
- b) ejecting the suspension through a narrow substantially straight ejecting conduit of substantially uniform cross-section;
- c) passing the pressurized suspension from the narrow ejecting conduit directly into an exit nozzle of sudden diameter increase into ambient pressure;
- and
- d) depressurizing the suspension to de-agglomerate the suspension.
A method of generating a fine aerosol from an agglomerated powder wherein clogging of an aerosol generator is avoided comprising the following steps:
- a) agitating and loading with a pressurized gas an agglomerated powder to create a pressurized suspension in the aerosol generator;
- b) ejecting the suspension through a narrow ejecting conduit in the aerosol generator;
- c) passing the pressurized suspension from the narrow conduit directly into an exit nozzle of sudden diameter increase into ambient pressure;
- and
- d) depressurizing the suspension to de-agglomerate the suspension.
A method of generating a fine aerosol from a powder substance comprising the following steps:
- a) agitating and loading with a pressurized gas a powder substance to create a pressurized suspension;
- b) ejecting the suspension through a narrow ejecting conduit of substantially uniform cross-section;
- c) passing the pressurized suspension from the narrow conduit directly into an exit nozzle of sudden diameter increase into ambient pressure;
- and
- d) depressurizing the suspension to de-agglomerate the suspension.
Dependencies are inferred from the claim text.