Depth-resolved spectroscopic optical coherence tomography
OwnerJoseph A. Izatt, Manish D. Kulkarni +1inventors
InventorsJoseph A. Izatt, Manish D. Kulkarni, Michael V. Sivak
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Abstract
A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.
Claims15
A method for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of:
- acquiring a plurality of sets of cross-correlation interferogramn data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition;
- and
- averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.
A method for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of:
- acquiring auto-correlation data from a low-coherence source interferometer, the low-coherence source interferometer including a sample arm;
- acquiring multiple cross-correlation data from the low-coherence source interferometer, wherein the low-coherence source interferometer includes a sample in its sample arm;
- obtaining an auto-power spectrum for a windowed portion of the auto-correlation data;
- obtaining a cross-power spectrum for a windowed portion of each cross-correlation data;
- obtaining a transfer function for each cross-correlation data by taking a ratio of the windowed cross-power spectrum to the auto-power spectrum;
- squaring each transfer function;
- and
- averaging the magnitude of the squared transfer functions.
An optical coherence tomography system comprising:
- an interferometer including an optical radiation source and a sample arm, the interferometer generating a plurality of cross-correlation data outputs for a sample in the sample arm;
- and
- a data processing system, operatively coupled to an output of the interferometer, averaging the cross-correlation data outputs, in the Fourier domain, to reveal backscattering characteristics of scatterers within the sample.
Dependencies are inferred from the claim text.