Chemical imaging system

Abstract

A Raman chemical imaging system uses a laser illumination source for illuminating an area of a sample. The spectrum of scattered light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. An Evans Split-Element type liquid crystal tunable filter (LCTF) selects a Raman image of the collimated beam. A detector collects the filtered Raman images which are subsequently processed to determine the constituent materials. The Evans Split-Element-type LCTF suitable for high-definition Raman chemical imaging is incorporated into an efficient Raman imaging system that provides significant performance advantages relative to any previous approach to Raman microscopy. The LCTF and associated optical path is physically compact, which accommodates integration of the LCTF within an infinity-corrected optical microscope. The LCTF simultaneously provides diffraction-limited spatial resolution and 9 cm.sup.-1 spectral bandpass across the full free spectral range of the imaging spectrometer. The LCTF Raman microscope successfully integrates the utility of optical imaging and the analytical capabilities of Raman spectroscopy which has practical significance in materials analysis, including the diagnosis of cancer.

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