20.alpha.-alpha-hydroxy steroid dehydrogenase related material and methods
AssigneeThe Board of Trustees of the Univeristy of Illinois
InventorGeula Gibori
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Abstract
The present invention relates generally to methods of inducing contraceptive or abortive effects via modulation of levels of circulating hormones via administration of an enzyme, pharmaceutical compositions achieving such effects, antibody substances immunoreactive to said enzyme and related substances, and methods for screening for the predisposition of spontaneous abortions
Claims4
A method of inducing abortion or preventing nidation in a mammal comprising reducing circulating blood levels of progesterone in said mammal by administration to the mammal an effective amount of a composition comprising 20.alpha.-hydroxysteroid dehydrogenase wherein said composition further comprises a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH).
Dependencies are inferred from the claim text.