# US 5,997,926 A · Antifungal complexes

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- Number: US 5,997,926 A
- Document ID: US5997926A
- Status: Granted
- Kind: A
- Application number: 09/042,134
- Filed: 1998-03-13
- Granted: 1999-12-07
- Earliest claimed: 1997-03-14
- Assignees: Gist-Brocades N.V.
- Inventors: Ferdinand Theodorus Jozef van Rijn; Jacobus Stark; Edith Magda Lucia Geijp
- Web page: https://patentgrep.com/patent/US5997926A

## CPC

- A23B 2/7295: {Antibiotics}
- C12P 19/626: {Natamycin; Pimaricin; Tennecetin}
- A23B: PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}

## Abstract

A complex containing natamycin complexed to one or more proteins. Processes for producing the same. Compositions containing the same. Use of the complexes as a preventative antimycobacterial treatment for natural products. A method for preventing the infection of a natural product by mycobacteria the method containing treating the natural with the complex.

## Claims

### Claim 1

A method for preventing the infection by mycobacteria of a natural product comprising treating a natural product with a natamycin complexed to one or more proteins or amino acids, when present in water, does not produce crystals visible at 400.times. magnification.

### Claim 2

A natural product which has been treated with a natamycin complexed to one or more proteins or amino acids, when present in water, does not produce crystals visible at 400.times. magnification.

### Claim 3

A method for preventing infection by mycobacteria of a natural product comprising treating the natural product with a composition comprising natamycin complexed to one or more proteins or amino acids, when present in water, which does not produce crystals visible at 400.times. magnification and does not substantially lose activity within 60 days and which also contains a fat or oil.

### Claim 4

A natural product that has been treated with a composition comprising natamycin complexed to one or more proteins or amino acids, when present in water, which does not produce crystals visible at 400.times. magnification and does not substantially lose activity within 60 days and which also contains a fat or oil.