Cochleate delivery vehicles
AssigneesAlbany Medical College, University of Medicine and Dentistry of New Jersey
InventorsSusan Gould-Fogerite, Raphael James Mannino
Life of this patent
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Abstract
The instant disclosure relates to cochleates comprising a) a biologically relevant molecule component b) a negatively charged lipid component, and c) a divalent cation component. The cochleate has an extended shelf life, even in a desiccated state. Advantageously, the cochleate can be ingested. The biologically relevant molecule can be a topical application and an in vitro treatment, a polypeptide a drug, a nutrient, or a flavor.
Claims59
A nutrient-cochleate formulation comprising:
- a) a nutrient component and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of delivering a nutrient to a cell in a host comprising administering to said host a biologically effective amount of cochleatc fonmulation comprising:
- a) a nutrient component and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A cochleate formulation comprising:
- a) a soluble protein or soluble polypeptide and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of delivering a soluble protein or soluble polypeptide to a cell in a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) a soluble protein or soluble polypeptide and
- b) a cochleate further comprising a negatively charged lipid and a divalent cation component.
A lipophilie drug-cochleate formulation comprising:
- a) a lipophilic drug and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of delivering a lipophilic drug to a cell in a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) a lipophilic drug component and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A pigient-cochleate formulation comprising:
- a) a pigment and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of delivering a pigment to a cell in a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) a pigment and
- b) a cochleate further comprising a negatively chargced lipid component and a divalent cation component.
A metal-cochleate formulation comprising:
- a) a metal and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of delivering a metal to a cell in a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) a metal and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A compound with a multi-ring structure-cochleate formulation comprising:
- a) a compound with a multi-ring structure and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of administering a compound with a multi-ring structure to a cell in a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) a compound with a multi-ring structure and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A saccharide-cochleate formulation comprising:
- a) a saccharide and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of administering a saccharide to a cell in a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) a saccharide and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
An enzyme-cochleate formulation comprising:
- a) an enzyme and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of administering an enzyme to a cell in a host comprising administering a biologically effective amount of a cochleate formulation comprising:
- a) a enzyme and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A co-factor-cochleate formulation comprising:
- a) a co-factor and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of administering a co-factor to a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) a co-factor and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
An adjuvant-cochleate formulation comprising:
- a) an adjuvant and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of administering an adjuvant to a host comprising administering to said host a biologically effective amount of a cochleate formulation comprising:
- a) an adjuvant and
- b) a cochleate further comprising a negatively chargced lipid component and a divalent cation component.
A method of delivering a biologically relevant molecule to a cell comprising contacting said cell with a cochleate formulation comprising:
- a) at least one biologically relevant molecule component and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A method of delivering a biologically relevant molecule to a host comprising topically applying to said host a biologically effective amount of a cochleate formulation comprising:
- a) at least one biologically relevant molecule component and
- b) a cochleate further comprising a negatively charged lipid component and a divalent cation component.
A flavor-cochleate formulation comprising:
- a) at least one flavor, and
- b) a cochleate further comprising at least one negatively charged lipid component, and at least one divalent cation component.
Dependencies are inferred from the claim text.