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US 5,994,315 AGranted
Low adenosine agent, composition, kit and method for treatment of airway disease
AssigneeEast Carolina University
InventorsJonathan W. Nyce, W. James Metzger
Life of this patent
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Abstract
An oligonucleotide which is antisense to a mRNA encoding a polypeptide involved in airway disease(s) contains up to three adenosines per every 21 nucleotide a method of treating airway disease in a subject in need of such treatment comprises topically administering to the subject an antisense oligonucleotide in an amount effective to treat the airway disease, where the antisense oligonucleotide is essentially free of adenosine. Pharmaceutical formulations are also disclosed.
Claims105
A pharmaceutical composition, comprising
- an oligonucleotide (oligo) in aerosol form, which is effective for aleviating bronchoconstriction or lung inflammation when administered to a mammal;
- wherein the oligo contains no more than 3 adenosines (A) or, if at least 21 nucleotides long, it contains no more than 3 per every 21 nucleouides;
- and
- is antisense to the initiation codon, the coding region or the 5' or 3' intron-exon junctions of a gene encoding an adenosine A.sub.1 receptor, adenosine A.sub.2a receptor, adenosine A.sub.2b receptor, or adenosine A.sub.3 receptor, or anti-sense to their respective mRNAs;
- and
- a pharmaceutically acceptable carrier.
3 more elements
The method of clam 47, wherein the mammalian subject is a human.
Dependencies are inferred from the claim text.