Nitrosated and nitrosylated .alpha.-adrenergic receptor antagonist compounds, compositions and their uses

A nitrosated or nitrosylated .alpha.-adrenergic receptor antagonist which is a compound having the structure:

• ##STR37## wherein R.sub.g is:
• ##STR38## wherein D.sub.1 is hydrogen or D, wherein D is (i) --NO, (ii) --NO.sub.2 ;
• (iii) --C(R.sub.d)--O--C(O)--Y--Z--(C(R.sub.e)(R.sub.f)).sub.p --T--Q;
• (iv) --(CO)--T.sup.1 --Z--(C(R.sub.e)(R.sub.f)).sub.p --T.sup.2 --Q;
• or (v) --C(O)--T(C(R.sub.y)(R.sub.z)).sub.p ;
• wherein R.sub.d is a hydrogen, a lower alkyl, or a cycloalkyl, or R.sub.d is a lower alkyl appended to a mono- or bi-cyclic carbocyclic ring system having one or two aromatic rings which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, and nitro, or R.sub.d is a mono- or bi-cyclic carbocyclic ring system having one or two aromatic rings which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, and nitro, or R.sub.d is a mono- or bi-cyclic ring system containing one or two aromatic rings and comprising at least one nitrogen, oxygen or sulfur atom in at least one aromatic ring, which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo and nitro;
• Y is oxygen, sulfur, or NR.sub.i wherein R.sub.i is a hydrogen or a lower alkyl;
• R.sub.e and R.sub.f are each independently a hydrogen, a lower alkyl, a cycloalkyl, an amino, an alkylamino, a dialkylamino, an amido, an alkylamido or a carboxy, or R.sub.e and R.sub.f are independently a lower alkyl appended to a mono- or bi-cyclic carbocyclic ring system having one or two aromatic rings which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, and nitro, or R.sub.e and R.sub.f are independently a mono- or bi-cyclic carbocyclic ring system having one or two aromatic rings which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, and nitro, or R.sub.e and R.sub.f are independently a mono- or bi-cyclic ring system containing one or two aromatic rings and comprising at least one nitrogen, oxygen or sulfur atom in at least one aromatic ring and where the aromatic rings are unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo and nitro, or R.sub.e and R.sub.f taken together are a carbonyl, a cycloalkyl or a bridged cycloalkyl;
• Z is a covalent bond, an alkyl, or a cycloalkyl, or Z is a mono- or bi-cyclic carbocyclic ring system having one or two aromatic rings which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo and nitro, or Z is lower alkyl appended to a mono- or bi-cyclic carbocyclic ring system having one or two aromatic rings which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo and nitro, or Z is a mono- or bi-cyclic ring system containing one or two aromatic rings and containing at least one nitrogen, oxygen or sulfur atom in the aromatic ring and is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl,, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo and nitro, or Z is a bi- or tri-cyclic ring comprised of a mono- or bi-cyclic carbocyclic ring system having one or two aromatic rings which is unsubstituted or substituted with one, two or three substituents independently selected from lower alkyl, haloalkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, halo and nitro that is appended via two adjacent carbon atoms to a 3-, 4-, 5-, 6-, or 7-membered nonaromatic ring containing at least one nitrogen, oxygen or sulfur atom;
• p is an integer from 1 to 6;
• T is a covalent bond, oxygen, sulfur or nitrogen;
• Q is --NO or --NO.sub.2 ;
• T.sup.1 and T.sup.2 are independently selected from T;
• and R.sub.y and R.sub.z are independently selected from --T.sup.1 --(C(R.sub.e)(R.sub.f)).sub.p --G--(C(R.sub.e)(R.sub.f)).sub.p --T.sup.2 --Q wherein T.sup.1, T.sup.2, T, R.sub.e R.sub.f, p and Q are as defined above and G is a covalent bond, --T--C(O)--, --C(O)--T--, or Y;
• wherein Y and T are as defined above;
• with the proviso that D.sub.1 must be D if there is no other D in the molecule.