Hydrophilic and hydrophobic polyether polyurethanes and uses therefor

An article of manufacture comprising:

• a substrate carrying a first layer of a hydrophilic polyether polyurethane, said polyurethane comprising the reaction product of a hydrophilic diol of at least about 60% by weight of the reaction mixture of polyoxyethylene diol having a number average molecular weight of from about 400 to about 20,000;
• a catalyst:
• an organic diisocyanate;
• and
• water in an amount by weight of from about 0.03% to about 0.45% of the reaction mixture, the ratio of NCO to OH of the diols, and water being from about 0.88 to about 0.99;
• and
• an active agent added to said polyurethane, said active agent selected from a pharmacologically active agent, an antithrombogenic agent, anticancer agent, cellular growth agent and an anticoagulant agent,
• wherein said active agent is entrapped for a period of time in said polyurethane.

An article of manufacture comprising:

• a substrate carrying a layer of an amphiphilic polyether polyurethane, said polyurethane comprising the reaction product of a mixture of:
• a hydrophilic diol of polyoxvethlene diol having a number average molecular weight of about 400 to about 20,000, the amount by weight of the hydrophilic diol in the reaction mixture being from about 1% to about 40%;
• at least one hydrophobic diol selected from the group consisting of polyoxytetramethylene diol having a number average molecular weight of from about 400 to about 3,000, polyoxypropylene diol having a number average molecular weight of from about 400 to about 3,000, polyether polycarbonate diol having a number average molecular weight of about 1,000 to about 2,400, polybutylene oxide having a number average molecular weight of about 1,000 to about 2,200, and polydimethylsiloxane polyoxyalkylene copolymer having a number average molecular weight of about 500 to about 3,800, wherein the polyoxyalkelene is selected from the group consisting of polyoxyethylene and polyoxypropylene, the amount by weight of the hydrophobic diol in the reaction mixture being from about 5% to about 70%;
• an alkylene glycol selected from the group consisting of ethylene glycol, propylene glycol, 2-ethyl-1,3-hexanediol, tripropylene glycol, triethylene glycol, 2,-4-pentane diol, 2-methyl-1,3-propanediol, 2,-methyl-1,3-pentanediol, cyclohexanediol, diethylene glycol, cyclohexanedimethanol, dipropylene glycol, and mixtures thereof,
• an organic diisocyanate;
• and
• water in an amount by weight of about 0.10% to about 0.50% of the reaction mixture, the ratio of NCO to OH of the diols, the alkylene glycol and the water being from about 0.90 to about 0.99, and
• an active agent added to said polyurethane, said active agent selected from a pharmacologically active agent, antithrombogenic agent, anticancer agent, cellular growth agent and anticoagulant agent, wherein said active agent is entrapped for a period of time in said polyurethane;
• a second layer coated over said first layer said second layer comprising:
• a hydrophilic diol of at least about 60% by weight of the reaction mixture of polyoxyethylene having a number average molecular weight of from about 400 to about 20,000;
• a catalyst;
• an organic diisocyanate;
• and
• water in an amount by weight of from about 0.03% to about 0.45% of the reaction mixture, the ratio of NCO to OH of the diols, and water being from about 0.88 to about 0.99.

An article of manufacture comprising:

• a substrate carrying a first layer of an amphiphilic polyether polyurethane, said polyurethane comprising the reaction product of a hydrophilic diol of at least about 60% by weight of the reaction mixture of polyoxyethylene diol having a number average molecular weight of from about 400 to about 20,000;
• a catalyst;
• an organic diisoyanate;
• water in an amount by weight of from about 0.03% to about 0.45% of the reaction mixture, the ratio of NCO to OH of the diols, and water being from about 0.88 to about 0.99;
• and
• an active agent added to said polyurethane, said active agent selected from a pharmacologically active agent, an antithrombogenic agent, anticancer agent, cellular growth agent and an anticoagulant agent, said active agent is entrapped for a period of time in said polyurethane;
• and
• a second layer coated over said first layer said second layer comprising a polyurethane comprising the reaction product of:
• a hydrophilic diol of polyoxyethlene diol having a number average molecular weight of about 400 to about 20,000, the amount by weight of the hydrophilic diol in the reaction mixture being from about 1% to about 40%;
• at least one hydrophobic diol selected from the group consisting of polyoxytetramethylene diol having a number average molecular weight of from about 400 to about 3,000, polyoxypropylene diol having a number average molecular weight of from about 400 to about 3,000, a polyether polycarbonate diol having a number average molecular weight of about 1,000 to about 2,400, and a polydimethylsiloxane polyoxyalkylene copolymer having a number average molecular weight of about 500 to about 3,800, wherein the polyoxyalklene is selected from the group consisting of polyoxyethylene and polyoxypropylene the amount by weight of the hydrophobic diol in the reaction mixture being from about 5% to about 70%;
• an alkylene glycol selected from the group consisting of ethylene glycol, propylene glycol, 2-ethyl-1,3-hexanediol, tripropylene glycol, triethylene glycol, 2,-4-pentane diol, 2methyl-1,3-propanediol, 2,-methyl-1,3-pentanediol, cyclohexanediol, diethylene glycol, cyclohexanedimethanol, dipropylene glycol, and mixtures thereof,
• an organic diisocyanate;
• and
• water in an amount by weight of about 0.10% to about 0.50% of the reaction mixture, the ratio of NCO to OH of the diols, the alkylene glycol and the water being from about 0.90 to about 0.99.

A coating formed of a hydrophilic polyether polyurethane, said polyurethane comprising the reaction product of a hydrophilic diol of at least 60% by weight of the reaction mire of polyoxyethylene diol having a number average molecular weight of from about 400 to about 20,000;

• a catalyst;
• an organic diisocyanate;
• and
• water in an amount by weight of from about 0.03% to about 0.45% of the reaction mixture, the ratio of NCO to OH of the diols, and water being from about 0.88 to about 0.99;
• and
• an active agent added to said polyurethane, said active agent selected from a pharmacologically active agent, an antithrombogenic agent, anticancer agent, cellular growth agent and an anticoagulant agent,
• wherein said active agent is entrapped for a period of time in said polyurethane.

A coating formed of a first layer of an amphiphilic polyether polyurethane, said polyurethane comprising the reaction product of a hydrophilic diol of at least 60% by weight of the reaction mixture of polyoxyethylene diol having a number average molecular weight of from about 400 to about 20,000;

• a catalyst;
• an organic diisocyanate;
• water in an amount by weight of from about 0.03% to about 0.45% of the reaction mixture, the ratio of NCO to OH of the diols, and water being from about 0.88 to about 0.99;
• and
• an active agent added to said polyurethane, said active agent selected from a pharmacologically active agent, an antithrombogenic agent, anticancer agent, cellular growth agent and an anticoagulant agent, wherein said active agent is entrapped for a period of time in said polyurethane;
• and
• a second layer coated over said first layer said second layer comprising a polyurethane comprising the reaction product of:
• a hydrophilic diol of polyoxyethlene diol having a number average molecular weight of about 400 to about 20,000, the amount by weight of the hydrophilic diol in the reaction mixture being from about 1% to about 40%;
• at least one hydrophobic diol selected from the group consisting of polyoxytetramethylene diol having a number average molecular weight of from about 400 to about 3,000, polyoxypropylene diol having a number average molecular weight of from about 400 to about 3,000, a polyether polycarbonate diol having a number average molecular weight of about 1,000 to about 2,400, and a polydimethylsiloxane polyoxyalkylene copolymer having a number average molecular weight of about 500 to about 3,800, wherein the polyoxyalkylene is selected from the group consisting of polyoxyethylene and polyoxypropylene, the amount by weight of the hydrophobic diol in the reaction mixture being from about 5% to about 70%;
• an alkylene glycol selected from the group consisting of ethylene glycol, propylene glycol, 2-ethyl-1,3-hexanediol, tripropylene glycol, triethylene glycol, 2,-4-pentane diol, 2methyl-1,3-propanediol, 2,-methyl-1,3-pentanediol, cyclohexanediol, diethylene glycol, cyclohexanedimethanol, dipropylene glycol, and mixtures thereof,
• an organic diisocyanate;
• and
• water in an amount by weight of about 0.10% to about 0.50% of the reaction mixture, the ratio of NCO to OH of the diols, the alkylene glycol and the water being from about 0.90 to about 0.99.

A coating formed of an amphiphilic polyurethane, said polyurethane comprising a reaction product of a hydrophilic diol of polyoxyethylene diol having a number average molecular weight of about 3,000 to about 20,000 in an amount by weight of about 50% to about 85% of the reaction mixture and a polyoxyethylene diol having a number average molecular weight of about 200 to about 2,000 in an amount of about 0.1% to about 25% by weight of the reaction mixture;

• and
• at least one hydrophobic polyoxyalkylene diol selected from the group consisting of polyoxypropylene having a number average molecular weight of about 400 to about 3000, a polyoxytetramethylene diol having a number average molecular weight of about 400 to about 3000, a polyether polycarbonate diol having a number average molecular weight of about 1000 to about 3000 polybutylene oxide having a number average molecular weight of about 200 to about 3000, a polydimethylsiloxane polyoxyalkylene copolymer having a number average molecular weight of about 500 to about 3200 wherein the polyoxyalkylene is selected from polyoxyethylene and polyoxypropylene, the amount by weight of the hydrophobic diol in the reaction mixture being from about 0.1% to about 30% by weight of the reaction mixture;
• organic diisocyanate;
• and
• water in an amount by weight of the reaction mixture of about 0.005% to about 0.30% in an equivalent mole weight ratio of NCO to OH of the diols, from about 0.85 to about 0.99.