Methods for prolonging the expression of a heterologous gene of interest using soluble CTLA4 molecules and an antiCD40 ligand
AssigneeBristol-Myers Squibb Company
InventorsPeter S. Linsley, Mark A. Kay, Christopher B. Wilson, Jeffrey Ledbetter, Alejandro A. Aruffo, Diane L. Hollenbaugh
Life of this patent
Estimating the term…
Abstract
The invention provides a method for enhancing the expression of a gene of interest by a cell, the cell (a) comprises a recombinant nucleic acid sequence encoding and (b) is capable of expressing the gene of interest, the method comprising contacting the cell with an amount of a soluble CTLA4 molecule effective to enhance the expression of the gene of interest by the cell.
Claims10
A method for inhibiting an immune response directed against an adenoviral vector in a subject, the method comprising introducing an adenoviral vector encoding a gene of interest into the subject and administering a sufficient amount of a soluble CTLA4 molecule and an antiCD40 ligand to the subject effective to inhibit the immune response directed against the adenoviral vector thereby increasing gene expression of the gene of interest in the subject.
Dependencies are inferred from the claim text.