Macroporous or microporous filtration membrane, method of preparation and use
AssigneeThe Research Foundation of State University of New York
InventorsEli Ruckenstein, Xianfang Zang
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Abstract
This invention relates to a microporous or macroporous affinity filtration membrane wherein the matrix is composed of chitosan or chitin and the pores are made by dissolution of porogen during the preparation of the membrane. The invention also relates to a method of preparation of the membrane comprising preparing an acidic chitosan solution containing porogen, shaping the suspension into a membrane, and dissolving the porogen by immersing the membrane in an alkaline solution. To prepare chitin membranes, the chitosan membranes are acetylated. The special feature of the membrane is that the pore size can be controlled by varying the size of the porogen. The membranes are suitable for affinity purification of macromolecules.
Claims40
A membrane selected from the group consisting of a microporous and macroporous membrane, wherein said membrane is composed of a matrix and a set or pores, wherein said matrix consists essentially of chitosan, and wherein said pores are formed by dissolution of a particulate porogen, wherein said pores are uniformly distributed and include a three-dimensional structure.
A membrane selected from the group consisting of a microporous membrane and macroporous membrane wherein said membrane is composed of a matrix and a set or pores, wherein said matrix comprises chitosan and at least one polymer selected from the group consisting of polyethylene oxide, polyvinyl alcohol, collagen and gelation, and wherein said pores are uniformly distributed and have a three dimensional structure.
The membrane according to claim, 1 wherein chitosan has a molecular weight of between about 400,000 to about 2,000,000.
Dependencies are inferred from the claim text.