US 5,989,815 A · Methods for detecting predisposition to cancer at the MTS gene

Abstract

The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Claims34

Dependent claims

A method for diagnosing a polymorphism associated with predisposition for cancer selected from the group consisting of melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, chronic lymphocytic leukemia (CLL), and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum, in a human comprising:

detecting a germline alteration of a wild-type Multiple Tumor Suppressor gene or its expression products in a human sample wherein said Multiple Tumor Suppressor gene or said expression product is a nucleic acid or a polypeptide defined by any one of the group of SEQ ID NOs:1-5, 13-16, 24 and 36, said alteration indicating a predisposition to at least one of said cancers.

Dependencies are inferred from the claim text.

Facts

Application

08/848,251Filed 29 Apr 1997 · continuation

Priority

18 Mar 1994

Granted

23 Nov 1999

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A01N 61/00
Biocides, pest repellants or attractants, or plant growth regulators containing substances of
C07H 21/02
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
C12Q 1/68
Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such…
C12Q 1/6886
For diseases caused by alterations of genetic material: for cancer

Family

Serial215,087Parent of this continuation-in-part · filed 18 Mar 1994

Serial215,086Parent of this continuation-in-part · filed 18 Mar 1994

Serial214,582Parent of this continuation-in-part · filed 18 Mar 1994

Serial227,369Parent of this continuation-in-part · filed 14 Apr 1994

Serial251,938Parent of this continuation-in-part · filed 1 Jun 1994

PCTUS9503537Parent of this continuation-in-part · filed 17 Mar 1995

Serial474,083Parent of this continuation · filed 7 Jun 1995

US 5,989,815 AThis patent

From the US filing history. Foreign family members aren’t listed.

Methods for detecting predisposition to cancer at the MTS gene

Life of this patent

Methods for detecting predisposition to cancer at the MTS gene

Life of this patent

Abstract

Claims34