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AssigneeAmerican Home Products Corporation
InventorsTerri Wasmoen, Hsien-Jue Chu, Lloyd Chavez
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The present invention provides recombinant raccoon poxviruses (RRPVs) useful in vaccines for the prophylaxis of disease caused by feline immunodeficiency virus (FIV). RRPVs according to the invention have at least one internal gene comprising a DNA sequence that encodes FIV gag protein (gag), FIV envelope protein (env), a polypeptide consisting of amino acids 1-735 of FIV env, or immunogenic fragments of any of the foregoing. The vaccines that comprise one or more of the FIV-expressing recombinant raccoon poxviruses described above may also comprise a pharmaceutically acceptable carrier or diluent and a pharmaceutically acceptable adjuvant. The invention also provides methods for preventing or lessening disease caused by FIV, which is carried out by administering to a feline in need of such treatment the vaccines described above.
A recombinant raccoon poxvirus having at least one internal gene comprising a DNA sequence encoding the gag protein of Feline Immunodeficiency Virus (FIV) or immunogenic fragments therefrom.
A vaccine for use in cats comprising:
A vaccine comprising:
A method for preventing or lessening disease caused by Feline Immunodeficiency Virus (FIV), comprising administering to a feline in need of such treatment a vaccine comprising a recombinant raccoon poxvirus having at least one internal gene comprising a DNA sequence encoding the envelope protein of Feline Immunodeficiency Virus (FIV) or immunogenic fragments therefrom.
A method for preventing or lessening disease caused by Feline Immunodeficiency Virus (FIV), comprising administering to a feline in need of such treatment a vaccine comprising a recombinant raccoon poxvirus having at least one internal gene comprising a DNA sequence encoding the gag protein of Feline Immunodeficiency Virus (FIV) or immunogenic fragments therefrom.
Dependencies are inferred from the claim text.