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US 5,986,131 AGranted
RXR selective ligands
AssigneeHoffmann-La Roche Inc.
InventorsMichael Klaus, Allen John Lovey, Peter Mohr, Michael Rosenberger
Life of this patent
Estimating the term…
Abstract
Novel nonatetraenoic acid derivatives which selectively bind to retinoic acid X-receptors (RXR) and which have anti-acne acitvity and which potentiate the activity of retinoids having RAR.alpha. activity are disclosed.
Claims11
A compound having the formula:
- ##STR9## wherein R".sub.1 and R".sub.2 are independently lower alkyl, or a pharmaceutically acceptable salt, ester or amide thereof.
A compound having the formula:
- ##STR10## wherein R".sub.1 and R".sub.2 taken together are C.sub.3-13 -alkylene in which one carbon atom may be substituted by a heteroatom selected from the group consisting of sulfur, oxygen and nitrogen, or a pharmaceutically acceptable salt, ester or amide thereof.
A compound having the formula:
- ##STR11## wherein R".sub.1 and R".sub.2 taken together with the carbon atoms to which they are attached are an aromatic ring having from 5-6 carbon atoms or a heteroaromatic ring having from 5-6 atoms in which one atom of R".sub.1 or R".sub.2 is a heteroatom selected from the group consisting of oxygen, nitrogen and sulfur and the remaining atoms of R".sub.1 and R".sub.2 are carbon, or a pharmaceutically acceptable salt, ester or amide thereof.
(2E,4E )-3-methyl-5-(2-((E)-2(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl)-1-cyclohe pten-1-yl)-2,4-pentadienoic acid.
(2E,4E)-3-Methyl-5-(2-((E)-2(2 ,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl)-1-cycloocten-1-yl)-2,4-pentadieno ic acid.
Dependencies are inferred from the claim text.