Zinc-based antiirritant creams
AssigneeThe Trustees of Columbia University in the City of New York
InventorsShanta Modak, Lester Sampath, Lauserpina Caraos
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Abstract
The present invention relates to the use of organic salts of zinc in topical formulations. Such organic salts tend to be less water soluble and therefore less likely to result in systemic toxicity, even with chronic use. In preferred embodiments, the composition of the invention comprise zinc salicylate, which provides the antiinflammatory effect of salicylate, but wherein the zinc moiety counteracts toxic effects associated with salicylate.
Claims7
A topical composition comprising:
- (a) between about 1 and 15 percent by weight of zinc stearate;
- and
- (b) between about 0.1 and 1 percent by weight of zinc salicylate;
- in a topical cream base.
A method for decreasing irritation of the skin of a subject comprising applying a therapeutically effective amount of an antiirritant cream to at least a portion of the skin of the subject, wherein the antiirritant cream comprises
- (a) between about 1 and 15 percent by weight of zinc stearate;
- and
- (b) between about 0.1 and 1 percent by weight of zinc salicylate;
- in a topical cream base.
Dependencies are inferred from the claim text.