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AssigneeNeoRx Corporation
InventorsLouis J. Theodore, Donald B. Axworthy, John M. Reno
Estimating the term…
Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are disclosed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic mechanisms encountered by compounds which are not so directed. Hepatic-directed compounds useful in the methods disclosed include a hexose cluster characterized by multiple hexose residues connected in an iteratively branched configuration. In one embodiment, the hexose cluster comprises at least four hexose residues with each branch of the configuration having two prongs. In another embodiment, the hexose cluster comprises at least nine hexose residues with each branch of the configuration having three prongs.
An improved method of therapy which comprises the administration of a compound comprising a binding moiety, targeting moiety or active agent, which is selectively delivered to a target sites, wherein the improvement comprises the addition of a reagent which provides for hepatic-directed clearance, wherein the reagent includes:
An improved method of therapy which comprises the administration of a compound comprising a binding moiety, targeting moiety or active agent, which is selectively delivered to a target site, wherein the improvement comprises the addition of a reagent which provides for hepatic clearance, wherein the reagent includes:
An improved method of therapy which comprises the administration of a compound comprising a binding moiety, targeting moiety or active agent, which is selectively delivered to a target site, wherein the improvement comprises the addition of a reagent which provides for hepatic clearance, wherein the reagent includes:
Dependencies are inferred from the claim text.