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US 5,983,131 AGranted
Apparatus and method for electroporation of tissue
AssigneeMassachusetts Institute of Technology
InventorsJames C. Weaver, Uwe Pliquett, Timothy Vaughan
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AssigneeMassachusetts Institute of Technology
InventorsJames C. Weaver, Uwe Pliquett, Timothy Vaughan
Estimating the term…
The present invention relates to an apparatus and method for localized electroporation of tissue. An apparatus includes a perforate electrically insulating layer, a first electrode at a first side of the perforate electrically insulating layer and a second electrode at a second side of the perforate electrically insulating layer. An electric field extending between the first and second electrodes will preferentially extend through perforations of the electrically insulating layer. The electric field thereby causes electroporation of tissue that is proximate to the first electrode and is partitioned from the electrically insulating layer and the second electrode by the first electrode. The apparatus controllably limits the depth of the electric field within a tissue, such as skin, thereby electroporating a surface layer, such as a stratum corneum layer of the skin, without stimulating submerged nerve endings within the skin. Sensation of the applied voltage and especially pain sensation can thereby be controlled by the invention.
An apparatus for electroporating a tissue, comprising:
A method for electroporating a tissue, comprising the steps of:
A method for causing iontophoresis in a tissue, comprising the steps of:
Dependencies are inferred from the claim text.