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US 5,981,467 AGranted
Aminimide-containing molecules and materials as molecular recognition agents
AssigneeArQule, Inc.
InventorJoseph C. Hogan, Jr.
Life of this patent
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Abstract
The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.
Claims9
A composition having the structure ##STR107## wherein a. A and B are the same or different, and each is a chemical bond;
- hydrogen;
- an electrophilic group;
- a nucleophilic group;
- R;
- an amino acid derivative;
- a nucleotide derivative;
- a carbohydrate derivative;
- a reporter element;
- an organic moiety containing a polymerizable group;
- or a macromolecular component, wherein A and B are optionally connected to each other or to other structures and R is as defined below;
- b. X and Y are the same or different and each represents a chemical bond or one or more atoms of carbon, nitrogen, sulfur, oxygen or combination thereof;
- c. R and R' are the same or different and each is an alkyl, cycloalkyl, aryl, aralkyl or alkaryl group or a substituted or heterocyclic derivative thereof, wherein R and R' may be different in adjacent n units and have a selected stereochemical arrangement about the nitrogen atom to which they are attached;
- d. G is a chemical bond or a connecting group that includes a terminal carbon atom for attachment to the quaternary nitrogen and G may be different in adjacent n units;
- and
- e. n.gtoreq.2;
- provided that if G is a chemical bond, Y includes a terminal carbon atom for attachment to the quaternary nitrogen.
13 more elements
Dependencies are inferred from the claim text.