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AssigneeNew York Blood Center, Inc.
InventorsBernard Horowitz, Bolanle Williams, Henrietta Margolis-Nunno, Sing N. Chin
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The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
In a process for treating an extracorporeal biological composition to inactivate an extracellular or intracellular virus which may be present therein, said process comprising the step of subjecting said composition to a virucidally effective amount of artificial irradiation, wherein the improvement comprises carrying out said step in the presence of (a) a mixture of at least one quencher compound that is effective to quench type I free radical medicated photodynamic reactions and at least one quencher compound that is effective to quench type II reactive forms of oxygen mediated photodynamic reactions or (b) a quencher compound that is effective to quench both type I and type II reactions.
In a process for treating an extracorporeal biological composition to inactivate an extracellular or intracellular virus which may be present therein, said process comprising the step of subjecting said biological composition to a virucidally effective amount of artificial irradiation, wherein said artificial irradiation is selected from the group consisting of artificial ultraviolet, gamma-irradiation, x-ray and visible light, wherein the improvement comprises carrying out said step in the presence of (a) a mixture of at least one quencher compound which is effective to quench type I free radical mediated photodynamic reactions and at least one quencher compound which is effective to quench type II reactive forms of oxygen mediated photodynamic reactions or (b) a quencher compound which is effective to quench both type I and type II photodynamic reactions.
A process comprising the step of subjecting an extracorporeal biological composition to a virucidally effective amount of artificial irradiation in the presence of rutin, wherein said artificial irradiation is selected from the group consisting of artificial ultraviolet, gamma-irradiation, x-ray and visible light.
Dependencies are inferred from the claim text.