Multiple emulsions comprising a hydrophobic continuous phase
AssigneeAlliance Pharmaceutical Corp.
InventorsMarie-Pierre Krafft, Jean G. Riess, Leila Zarif
Life of this patent
Estimating the term…
Abstract
Multiple emulsions comprising a discontinuous emulsified phase incorporating a highly polar liquid, a second component selected from the group consisting of fluorocarbons and hydrocarbons and a continuous hydrophobic phase are disclosed. In preferred embodiments, the hydrophobic phase may comprise a fluorocarbon or hydrocarbon. Additionally, the stable multiple emulsions of the present invention may further incorporate a bioactive agent and are particularly suitable for drug delivery including pulmonary drug delivery.
Claims30
A stable multiple emulsion for the delivery of bioactive agents comprising:
- a discontinuous emulsified phase comprising a first dispersant, a polar liquid and a second component selected from the group consisting of fluorocarbons and hydrocarbon oils wherein the second component is dispersed in the polar liquid or the polar liquid is dispersed in the second component;
- a continuous phase comprising a hydrophobic compound;
- and
- an effective dispersing amount of a second dispersant wherein said discontinuous emulsified phase is immiscible in said hydrophobic compound.
A method for forming a stable multiple emulsion comprising the steps of:
- emulsifying a first dispersant a polar liquid and a second component selected from the group consisting of fluorocarbons and hydrocarbons wherein the second component is dispersed in the polar liquid or the polar liquid is dispersed in the second component to provide an emulsified disperse phase;
- and
- dispersing said emulsified disperse phase in a continuous phase comprising a hydrophobic compound and a second dispersant wherein said emulsified disperse phase is immiscible in said hydrophobic compound.
A method for delivering a bioactive agent to a patient in need thereof comprising:
- providing a bioactive emulsion comprising a discontinuous emulsified phase having therein a first dispersant, a polar liquid and a second component selected from the group consisting of fluorocarbons and hydrocarbons wherein the second component is dispersed in the polar liquid or the polar liquid is dispersed in the second component, said emulsified phase dispersed in a continuous phase comprising a hydrophobic compound and an effective dispersing amount of a second dispersant wherein said emulsified disperse phase is immiscible in said hydrophobic compound and wherein said bioactive multiple emulsion further comprises at least one bioactive agent;
- and
- administering said bioactive multiple emulsion to a patient.
Dependencies are inferred from the claim text.