Methods for enhancing angiogenesis with endothelial progenitor cells
AssigneeSt. Elizabeth's Medical Center of Boston, Inc.
InventorsJeffrey M. Isner, Takayuki Asahara
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Abstract
In accordance with the present invention, EC progenitors can be used in a method for regulating angiogenesis, i.e., enhancing or inhibiting blood vessel formation, in a selected patient and in some preferred embodiments for targetting specific locations. For example, the EC progenitors can be used to enhance angiogenesis or to deliver an angiogenesis modulator, e.g. anti- or pro-angiogenic agents, respectively to sites of pathologic or utilitarian angiogenesis. Additionally, in another embodiment, EC progenitors can be used to induce reendothelialization of an injured blood vessel, and thus reduce restenosis by indirectly inhibiting smooth muscle cell proliferation.
Claims11
A method for inducing the formation of new blood vessels in an ischemic tissue in a patient in need thereof, comprising:
- administering to said patient host an effective amount of an isolated endothelial progenitor cell to induce new blood vessel formation in said ischemic tissue, wherein said endothelial progenitor cell are CD34.sup.+, flk-1.sup.+ or tie-2.sup.+.
A method of enhancing blood vessel formation in a patient in need thereof, comprising:
- a. selecting the patient in need thereof;
- b. isolating endothelial progenitor cells from the patient, wherein said endothelial progenitor cell are CD34.sup.+, flk-1.sup.+ or tie-2.sup.+ ;
- and
- c. readministering the endothelial progenitor cells to the patient.
A method for treating an injured blood vessel in a patient in need thereof, comprising:
- a. selecting the patient in need thereof;
- and
- b. isolating endothelial progenitor cells from the patient, wherein said endothelial progenitor cell are CD34.sup.+, flk-1.sup.+ or tie-2.sup.+ ;
- and
- c. readministering the endothelial progenitor cells to the patient.
Dependencies are inferred from the claim text.