Antisense oligonucleotides for inhibiting helicobacter pylori activity
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorsEduardo Pirotzky, Soudhir Colote
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Abstract
Antisense oligonucleotides that selectively hybridise with one or more genes necessary for Helicobacter pylori (H. pylori) activity, and particularly with the CagA cytotoxicity-associated immunodominant antigen, flagellin (flaA and flaB) or vacuolating cytotoxin (vacA), are disclosed. Pharmaceutical compositions containing said antisense oligonucleotides, and the use thereof for treating atrophic gastritis, peptic and duodenal ulcers, gastric atrophy or stomach cancer, are also disclosed.
Claims12
An antisense oligonucleotide comprising 15 to 25 units which hybridizes selectively with the genes for the immuno-dominant antigen associated with CagA cytotoxicity and/or flagellin (flaA and flaB) and/or vaculizing cytotoxin (vacA) and said oligonucleotide is one of SEQ ID Nos:
- 1 to 24 or contains therein one of SEQ ID Nos:
- 1 to 24.
An antisense oligonucleotide consisting of 15 to 25 units wherein said antisense oligonucleotide comprises any one of SEQ ID Nos:
- 1-24.
Dependencies are inferred from the claim text.