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US 5,977,326 AGranted
Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
AssigneeSalford Ultrafine Chemicals and Research Limited
InventorsFeodor Scheinmann, Simon Joel, Andrew V. Stachulski
Life of this patent
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Abstract
The abstract isn’t available for this document.
Claims5
A compound of the following formula (I):
- ##STR11## wherein positions 7, 8 is dihydro-, dihydroxy-, hydroxyhalo-, epoxy-, dihalo-, hydrohalo-, hydrohydroxy-, or CXY (X,Y is halogen or hydrogen) adducts.
A pharmaceutical composition comprising a pharmaceutically effective amount of a compound of formula I:
- ##STR12## or a pharmaceutically acceptable salt thereof.
A method for the treatment of chronic or acute pain, or a morphine overdose comprising administering to an animal or human patient in need thereof a pharmaceutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:
- ##STR13##
A process for making a compound of the formula (I):
- comprising:
- (a) protecting the 3-phenolic group of morphine sulfate by acylation,
- (b) protecting the hydroxyl and carboxylic acid groups of D-glucuronolactone.
- (c) condensing the products of steps (a) and(b),
- (d) removing the protecting groups of the condensation product obtained in step(c) to yield morphine-6-glucuronide, and
- (e) hydrogenating the morphine-6-glucuronide.
3 more elements
Dependencies are inferred from the claim text.