CTLA4 receptor and uses thereof
AssigneeBristol-Myers Squibb Company
InventorsPeter S. Linsley, Jeffrey A. Ledbetter, Nitin K. Damle, William Brady, Peter A. Kiener
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Abstract
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
Claims4
A monoclonal antibody which recognizes and binds the extracellular domain of CTLA4, wherein said binding prevents the binding of CTLA4 to the B7 antigen.
Dependencies are inferred from the claim text.